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dc.contributor.author	García Anaya, María de Lourdes
dc.contributor.author	GONZALEZ OLVERA, JORGE JULIO
dc.contributor.author	RICARDO GARCELL, JOSEFINA
dc.contributor.author	ARMAS CASTAÑEDA, GABRIELA
dc.contributor.author	MIRANDA PANIAGUA, EDGAR
dc.contributor.author	REYES ZAMORANO, ERNESTO
dc.contributor.author	OTERO OJEDA, GLORIA ADELINA
dc.creator	García Anaya, María de Lourdes; 162249
dc.creator	GONZALEZ OLVERA, JORGE JULIO; 96748
dc.creator	RICARDO GARCELL, JOSEFINA; 25455
dc.creator	ARMAS CASTAÑEDA, GABRIELA; 248994
dc.creator	MIRANDA PANIAGUA, EDGAR; 519491
dc.creator	REYES ZAMORANO, ERNESTO; 47954
dc.creator	OTERO OJEDA, GLORIA ADELINA; 15825
dc.date.accessioned	2016-03-16T17:17:46Z
dc.date.available	2016-03-16T17:17:46Z
dc.date.issued	2011
dc.identifier	http://www.redalyc.org/articulo.oa?id=58221317001
dc.identifier.uri	http://hdl.handle.net/20.500.11799/39428
dc.description	Major Depressive Disorder (MDD) is a common psychiatric disorder that represents one of the main public health problems worldwide. It has been projected that for 2020 it will be the second cause of disability-adjusted life years just below ischemic heart disease. Quantitative electroencephalogram provides the opportunity to study cortical oscillatory activity across the different frequency bands. It constitutes an accessible tool to explore the clinical and neurophysiologic correlates underlying psychiatric disorders as well as the effect of diverse therapeutic options and the performance through cognitive tasks. Repetitive transcranial magnetic stimulation is a technique that allows the stimulation of the cerebral cortex noninvasively, relatively painlessly and with fairly few side effects. The vast majority of rTMS studies target left dorsolateral prefrontal cortex (DLPFC) based on imaging studies showing that left prefrontal cortex dysfunction is pathophysiologically linked to depression. However, there is some evidence implicating right PFC in the pathophysiology of depression. Comparison of antidepressant efficacy of diverse stimulation frequencies is relevant since a main concern around rTMS is its potential to induce seizures; hence we consider that frequency of stimulation is an important aspect to be studied. For this study we aimed to elucidate the clinical efficacy of rTMS comparing two groups of depressed patients stimulated over DLPFC, one over the left (at 5 Hz) and other over the right (at 1 Hz). We also meant to know if there were clinical and electroencephalographic differential long-term after-effects between those groups of treatment. We included twenty right-handed patients with a DSM-IVR diagnosis of MDD. They were assigned into two groups of treatment. Group 1 received 5Hz rTMS over the left DLPFC. Group 2 received 1Hz rTMS over the right DLPFC. We obtained two EEG measurements in order to analyze Z score of broad-band spectral parameters and cross-spectral. No statistical differences among groups were found in response to treatment after weekly comparisons of clinimetric scores and significant differences between baseline and final assessment by HDRS, MADRS, BDI and HARS. The major rTMS effect on EEG was observed in the group that received 1 Hz over the right DLPFC and no significant effects were observed for the group that received 5 Hz over the left DLPFC. Our results propose that administration of 15 sessions on either left (5 Hz) or right (1 Hz) rTMS over DLPFC is sufficient to reach response to treatment, assessed by HDRS, MADRS, BDI and HARS in subjects with MDD. Moreover, in both cases rTMS was able to induce an equivalent antidepressant effect. The major effect of rTMS on EEG was observed in the right 1 Hz rTMS group where changes were elicited mainly over frontal, central and temporal regions on alpha and particularly beta frequency bands. In a lesser extent for left 5 Hz rTMS group the main effect was observed on anterior regions for beta and particularly alpha frequency bands. We believe it is pertinent to continue exploring the therapeutic potential of lower stimulation frequencies, for what further research including larger samples is still necessary to confirm these trends.
dc.format	application/pdf
dc.language.iso	eng	es
dc.publisher	Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.relation	http://www.redalyc.org/revista.oa?id=582
dc.rights	Salud Mental
dc.rights	openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0
dc.source	Salud Mental (México) Num.4 Vol.34
dc.subject	Medicina	es
dc.subject	Major depressive disorder	es
dc.subject	rTMS	es
dc.subject	EEG	es
dc.subject	laterality	es
dc.subject	5Hz	es
dc.subject	1Hz	es
dc.subject.classification	MEDICINA Y CIENCIAS DE LA SALUD
dc.title	Clinical and electrophysiological effect of right and left repetitive transcranial magnetic stimulation in patients with major depressive disorder	es
dc.type	Artículo	es
dc.provenance	Científica	es
dc.road	Dorada	es
dc.ambito	Internacional	es
dc.audience	students	es
dc.audience	researchers	es
dc.type.conacyt	article
dc.identificator	3

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